TT01001 是 mitoNEET 的选择性激动剂，通过改善线粒体功能障碍来减少氧化应激损伤和神经元凋亡。 TT01001可用于治疗II型糖尿病的研究。

TT01001 is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.

In type II diabetes model db/db mice, TT01001 improved hyperglycemia, hyperlipidemia, and glucose intolerance, and its efficacy was equivalent to that of pioglitazone, without the pioglitazone-associated weight gain. Mitochondrial complex II + III activity of the skeletal muscle was significantly increased in db/db mice. TT01001 significantly suppressed the elevated activity of the complex II + III[2].

1022367-69-6

C15H19Cl2N3O2S

376.3

Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate;TT-01001

DMSO:18 mg/mL (47.8 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years