Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.

In the screening of inhibitors of Staphylococcus aureus enoyl-ACP reductase (FabI), we found that a methanol extract of leaves of Morus alba L. potently inhibited S. aureus FabI as well as growth of S. aureus. The active principles were identified as chalcomoracin and Moracin C by MS and NMR analysis. Chalcomoracin and Moracin C inhibited S. aureus FabI with IC(50) of 5.5 and 83.8 μM, respectively. They also prevented the growth of S. aureus with minimum inhibitory concentration (MIC) of 4 and 32 μg/mL, respectively. Consistent with their inhibition against FabI and bacterial growth, they prevented (14)C]acetate incorporation into fatty acid in S. aureus while didn't affect protein synthesis.

69120-06-5

C19H18O4

310.34

桑辛素 C;5-(6-羟基-2-苯并呋喃基)-2-(3-甲基-2-丁烯基)-1,3-苯二醇

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years