ImreCOXib 是COX1和COX2的抑制剂，IC50值为 115 和 18 nM，具有抗炎作用。
产品描述
Imrecoxib is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM). It also inhibits COX1- activity (IC50: 115 nM). Imrecoxib has an anti-inflammatory effect.
体外活性
In U937 cells, Imrecoxib (0.1-10 μM; 24 hours) reduces COX-2 mRNA level induced by PMA+LPS in a dose-dependent manner.
体内活性
Imrecoxib (gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days) diminishes the secondary paw swelling. It also inhibits heat-inactivated BCG induced-inflammtory polyarthritis. Imrecoxib (gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection) suppresses carrageenan-induced acute inflammation, and the inhibitory effect is maximal at 4 hours.
Cas No.
395683-14-4
分子式
C21H23NO3S
分子量
369.48
别名
艾瑞昔布;BAP-909
储存和溶解度
DMSO:90 mg/mL (243.59 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
