Indobufen 是一种血小板聚集抑制剂，是下调单核细胞中的组织因子，可逆抑制血小板环氧合酶 (COX) 的活性和血栓素 A2 (TxA2) 的合成。

Indobufen is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes.

Indobufen suppresses TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen causes the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered. Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels.

63610-08-2

C18H17NO3

295.33

Ibustrin;吲哚布芬

DMSO:250 mg/mL (846.51 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years