Luteolin是一种黄酮类Nrf2抑制剂，具有抗炎和抗癌特性，可在人类多种癌细胞系中诱导细胞凋亡和细胞周期停滞，并抑制细胞转移和血管生成。

Luteolin is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components of the human diet. In vitro work has concentrated on the direct and indirect actions of flavonoids on tumor cells, and has found a variety of anticancer effects such as cell growth and kinase activity inhibition, apoptosis induction, suppression of the secretion of matrix metalloproteinases and of tumor invasive behavior. Furthermore, some studies have reported the impairment of in vivo angiogenesis by dietary flavonoids. Experimental animal studies indicate that certain dietary flavonoids possess antitumoral activity.

小鼠：LD50>2500 mg/kg(i.g.)

Luteolin对产生脂多糖刺激的TNF-α有抑制作用（IC50<1 μM）。Luteolin对脂多糖诱导的Akt和IκB-α的磷酸化也有抑制效果。作为非选择性的磷酸二酯酶PDE抑制剂,Luteolin对PDE1-5的Ki值分别为15.0 μM,6.4 μM,13.9 μM,11.1 μM以及9.5 μM。

491-70-3

C15H10O6

286.24

Flacitran;木犀草素;Luteoline;Digitoflavone;Luteolol

DMSO:57 mg/mL (199.13 mM)
H2O:<1 mgml
Ethanol:3 mg/mL (10.48 mM),warmed
Powder: -20°C for 3 years
In solvent: -80°C for 2 years