CDDO-EA 是 Nrf2/抗氧化反应元件的激活剂。
产品描述
CDDO-EA is an activator of the Nrf2/antioxidant response element.
体外活性
In a cell culture model of ALS, CDDO-EA potently activates Nrf2/ARE [1]. CDDO-EA induces apoptosis in A549 lung cancer cells and induces heme oxygenase-1. CDDO-EA is 7-fold more potent than CDDO as a suppressor of the ability of IFN-γ to induce iNOS in RAW264.7 macrophage-like cells[2].
体内活性
CDDO-EA-treated G93A mice live significantly longer than the control. CDDO-EA increases the life-span from 124.05 days to 144.72 days (16.6%). In CDDO-EA-treated G93A mice, the age of death is 141.4 days and the duration from the age of onset to the age of death is 57.6 days. The age of death from the onset is prolonged by 17.5 days (43%) [1].
Cas No.
932730-51-3
分子式
C33H46N2O3
分子量
518.73
别名
RTA 405;CDDO ethyl amide;TP319
储存和溶解度
DMSO:30 mg/mL (57.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
