ADU-S100 ammonium salt 是干扰素基因刺激物的激活剂。 ADU-S100 ammonium salt 可导致有效的全身性肿瘤消退和免疫。

ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.

ADU-S100 ammonium salt induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 ammonium salt is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage. ADU-S100 ammonium salt induces significantly higher levels of IFN-α compared to ML cGAMP[1].

IT injection of ADU-S100 ammonium salt into one tumor in BALB/c mice bearing bilateral CT26 or 4T1 tumors also demonstrated significant regression of the contralateral, untreated tumor. IT injection with ADU-S100 ammonium salt eradicates multiple tumor types and primes an effective systemic CD8+ T cell immune response that significantly inhibits the growth of distal, untreated lesions[1].

1638750-96-5

C20H30N12O10P2S2

724.6

MIW815 ammonium salt;ML RR-S2 CDA ammonium salt

H2O:5 mg/mL (6.90 mM),Need ultrasonic
DMSO:12 mg/mL (16.58 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years