Fluticasone furOATe 是一种合成的三氟化皮质类固醇，衍生自氟替卡松，Kd 为 0.3 nM。Fluticasone furOATe 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furOATe 可用作过敏性鼻炎治疗研究的鼻喷雾剂。

Fluticasone furoate is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure. Fluticasone furoate can be used as a nasal spray for studies about allergic rhinitis treatment.

Fluticasone furoate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furoate prevents damage to cultured human lung epithelial cells by different stimuli[2].

Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine. Fluticasone furonate is 99.4% bound to plasma protein in vitro. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme CYP3A4 that converts the drug to the 17β-carboxylic acid metabolite, which displays low glucocorticoid receptor agonist potency[2].

397864-44-7

C27H29F3O6S

538.58

Fluticasone furoate;Veramyst;Avamys;Allermist;糠酸氟替卡松

H2O:Insoluble
DMSO:95 mg/mL (176.39 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years