MRT-83 是一种 Smo 拮抗剂，其IC50值在纳摩尔级别。它能够抑制 Hedgehog 信号通路。
产品描述
MRT-83 is a potent Smo antagonist.
体外活性
MRT-83 blocks BC binding to HEK-hSmo cells in a dose-dependent manner with an IC50 of 4.6 nM. MRT-83 abrogates BC binding to cells expressing mouse Smo with an IC50 of 14 nM, which is in good correlation with its IC50 in the Shh-light2 and alkaline phosphatase assays[1].
体内活性
MRT-83 can't up-regulation of Ptc transcription in the SVZ of these animals in agreement with complete inhibition of ShhN-mediated effects (8.7±2.4 Ptc+ cells/section, n=9) and is not different from vehicle-mediated effects[1].
Cas No.
1263131-92-5
分子式
C31H30N4O5
分子量
538.59
储存和溶解度
DMSO:250mg/mL (464.17mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
