JLK-6 是一种γ分泌酶抑制剂，选择性作用于HEK293细胞的淀粉样β前体蛋白(APP)的γ-分泌酶裂解APP，抑制 Aβ的生成，但对不Notch受体的裂解无影响。
产品描述
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
体外活性
JLK6 markedly reduced Aβ secreted from HEK293 cells. Immunological characterization indicated that one fragment was labelled with a specific antibody against the Asp1 residue of Aβ[1].
Cas No.
62252-26-0
分子式
C10H8ClNO3
分子量
225.63
储存和溶解度
DMSO:22 mg/mL(97.50mM)
Ethanol:5mg/mL(22.16mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
