Peficitinib 是一种可口服的 JAK 抑制剂，对 JAK1、JAK2、JAK3 和 Tyk2 的IC50值分别为 3.9、5.0、0.7 和 4.8?nM。
产品描述
Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
体外活性
ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5). [1]
体内活性
In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score. [1]
Cas No.
944118-01-8
分子式
C18H22N4O2
分子量
326.4
别名
ASP015K;JNJ-54781532
储存和溶解度
H2O:<1 mgml
Ethanol:<1 mgml
DMSO:60 mg/mL (183.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
