BAI1 是一种选择性凋亡因子BAX变构抑制剂。它结合 BAX 并变构抑制其激活，具有潜力研究 BAX 依赖性细胞死亡介导的疾病。
产品描述
BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).
体外活性
V-9302 inhibited ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibited a 100-fold improvement in potency (IC50 V-9302 = 9.6 μM) over gamma-L-glutamyl-p-nitroanilide (GPNA; IC50 = 1000 μM). The EC50 concentration
Cas No.
335165-68-9
分子式
C19H21Br2N3O
分子量
467.20
储存和溶解度
H2O:Insoluble
DMSO:15 mg/mL (32.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
