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GR 46611
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GR 46611图片
CAS NO:185259-85-2
包装与价格:
包装价格(元)
1 mg询价
5 mg询价
10 mg询价
25 mg询价
50 mg询价
100 mg询价
1 mL*10 mM(in DMSO)询价

3-[3-[2-二甲基氨基乙基]-1H-吲哚-5-基]-N-[4-甲氧基苄基]丙烯酰胺
GR 46611 是一种选择性 5-HT1B 和 5-HT1D 受体激动剂,可用于治疗癫痫的研究。

产品描述

GR 46611 is a selective 5-HT1B and 5-HT1D receptor agonist and can be used in studies about the treatment of epilepsy.

体内活性

GR 46611 (0.6 and 6 nmol; paraventricular hypothalamic nucleus (PVN)) promptly and reliably elicited feeding at their higher doses, without affecting drinking or non-ingestive behaviors. GR 46611 (6 nmol) elicited intense feeding responses in the n. medialis hypothalami posterioris and in the adjacent n. lateralis hypothalami posterioris (PMH/PLH complex, in the caudoventral hypothalamus) and in the n. magnocellularis preopticus (PPM, in the caudal preoptic region)[1]. GR 46611 (1 mg/kg) significantly increased the threshold of hyperthermia-induced seizure and lowered seizure severity thereby improving the survival of DS mice[2].

Cas No.

185259-85-2

分子式

C23H27N3O2

分子量

377.48

别名

3-[3-[2-二甲基氨基乙基]-1H-吲哚-5-基]-N-[4-甲氧基苄基]丙烯酰胺

储存和溶解度

DMSO:11.3 mg/mL (30 mM)
Ethanol:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
 
 
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