Tropisetron Hydrochloride 是5-HT3受体拮抗剂和α7-烟碱受体激动剂，具有抗恶心和止吐活性，对5-HT3受体的IC50为70.1 nM。
产品描述
Tropisetron Hydrochloride is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinauseant and antiemetic activities.
体内活性
Tropisetron (1 mg/kg i.p.) significantly improves the deficient inhibitory processing of the P20-N40 auditory evoked potential in DBA/2 mice. [5]
Cas No.
105826-92-4
分子式
C17H21ClN2O2
分子量
320.82
别名
盐酸托烷司琼;SDZ-ICS 930;Tropisetron HCl;ICS 205-930
储存和溶解度
H2O:50 mg/mL (155.86 mM)
DMSO:33.33 mg/mL (103.89 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
