GET73 是天然神经递质 γ-羟基丁酸的类似物。它对谷氨酸在海马的传递有显著的影响。它具有抗酒精和抗焦虑的作用。
产品描述
GET73 is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.
体外活性
GET73 (1 μM, 10 μM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, an increase of reactive oxygen species production?and a decrease in extracellular glutamate levels.
体内活性
GET73 exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test.
Cas No.
202402-01-5
分子式
C13H16F3NO2
分子量
275.27
别名
Gamma hydroxybutyric acid analogue;GET 73
储存和溶解度
DMSO:97 mg/mL (352.38 mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
