MTEP hydrochloride 是非竞争性的mGlu5拮抗剂，IC50和Ki分别为 5 和16 nM，有抗帕金森病样作用。
产品描述
MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)
体内活性
Male Albino Swiss mice were used, and antidepressant-like activity was evaluated using the FST.?The antidepressant-like effect of MTEP (0.3 mg/kg) was significantly antagonized by pre-treatment with the NMDA receptor agonist N-methyl-D-aspartic acid (NMDA, 75 mg/kg)[1].
Cas No.
1186195-60-7
分子式
C11H9ClN2S
分子量
236.72
别名
MTEP;3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐;3-((2-Methyl-1,3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride
储存和溶解度
H2O:20 mg/mL (84.49 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
