Tiagabine 是具有抗惊厥特性的选择性GABA 再摄取抑制剂，在突触体、神经元和神经胶质中，能够抑制 [3H]GABA 的重摄取，IC50值分别为 67、446 和 182 nM。
产品描述
Tiagabine is an Anti-epileptic Agent. The physiologic effect of tiagabine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
体外活性
Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus[2]. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs[1].
体内活性
Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia[3].
Cas No.
115103-54-3
分子式
C20H25NO2S2
分子量
375.55
别名
噻加宾;NO328;TGB;Gabitril;NO050328
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
