LY2940094 是一种口服有效的选择性 NOP 受体拮抗剂，可降低动物模型的自身给药酒精依赖，对 NOP 受体具有高亲和力，Ki为 0.105 nM，和拮抗活力，Kb为 0.166 nM。

LY-2940094 decreases ethanol self-administration in animal models. LY-2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM).

In Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, LY-2940094 (3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently decreases homecage ethanol self-administration, without affecting food/water intake or locomotor activity.

1307245-86-8

C22H23ClF2N4O2S

480.96

LY-2940094

DMSO:41.67 mg/mL (86.64 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years