产品描述
Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).
体外活性
Higher Fura-2 transient amplitude after the pause upon Rimacalib vs. 37.2±4.3% in control and in parallel cardiomyocyte contractility (135.0±15.4% vs. 97.2±16% increase of twitch amplitude, p=0.098). Rimacalib improves (by ~40%) Ca2+-transient potentiation during the 30 s stimulation pause [1].
Cas No.
215174-50-8
分子式
C22H23FN4O2
分子量
394.44
别名
SMP 114
储存和溶解度
DMSO:125 mg/mL (316.90 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
