KI-7 是一种A2B腺苷受体阳性变构调节剂。它增强选择性 A2B 腺苷受体激动剂 BAY 60-6583 和腺苷诱导的 cAMP 积累，EC50分别为 2390 nM 和 2550 nM。它也增强非选择性 A2B 腺苷受体激动剂 NECA 诱导的 cAMP 积累，EC50为 445.8 nM。
产品描述
KI-7 is an adenosine A2B receptor positive allosteric modulator.
体外活性
KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively[1][2].
Cas No.
1489263-00-4
分子式
C23H18N2O2
分子量
354.4
储存和溶解度
DMSO:240 mg/mL (677.20 mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
