Tyrphostin AG1433 是选择性的PDGFRβ和VEGFR-2 (Flk-1/KDR)抑制剂，IC50分别为 5.0 μM 和 9.3 μM。Tyrphostin AG1433有防止血管形成的活性。

Tyrphostin AG1433 is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).

In glioblastoma cells, Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) treatment induces moderate cytotoxicity [1].

Tyrphostin AG1433 is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos, and prevents the formation of new yessels under the pellets[2].

168835-90-3

C16H14N2O2

266.29

SU1433;AG1433

DMSO:62.5 mg/mL (234.71 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years