产品描述
Corin is a dual inhibitor of histone lysine-specific demethylase (LSD1) and HDAC (Ki(inact): 110 nM for LSD1; IC50: 147 nM for HDAC1).
体外活性
Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275( EC50: 420 nM), Corin appears to more potently (EC50: 95 nM) and efficaciously induce cellular H3K9 acetylation. Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM).
Cas No.
1808113-09-8
分子式
C26H28N4O2
分子量
428.53
储存和溶解度
DMSO:100 mg/mL (233.36 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
