SGC-SMARCA-BRDVIII 是SMARCA2/4和PB1(5)选择性抑制剂，其Kd值分别为 35 nM，36 nM 和 13 nM。它还抑制PB1(2)和PB1(3)，Kd值分别为 3.7 和 2.0 μM。它可阻断 3T3-L1 鼠成纤维细胞的脂肪生成。

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.

SGC-SMARCA-BRDVIII blocks adipogenesis in 3T3-L1 murine fibroblasts[1].

1997319-84-2

C19H25N5O3

371.43

DMSO:50 mg/mL(134.61 mM)
Ethanol:5 mg/mL(13.46 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years