UMB298 是一种有效的选择性 CBP/P300 溴结构域抑制剂，抑制 BRD4，IC50 为 5193nM。
产品描述
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
体外活性
UMB298 inhibits MOLM13 and MM cells growth. UMB298 reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. UMB298 down-regulates MYC expression in MOLM13 cells.
Cas No.
2266569-73-5
分子式
C27H31ClN4O2
分子量
479.02
储存和溶解度
DMSO:20mg/ml(41.75mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
