BI7273 是一种选择性的可细胞透过BRD9抑制剂，IC50和Kd分别为 19 和 0.75 nM。它对 BRD7 的作用较强，IC50和Kd值分别为 117 和 0.3 nM。
产品描述
BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.
体外活性
BI-7273 blocks EOL-1 cell proliferation with EC50 of 1400 nM. BI-7273 (1 μM) is active in U2OS cell lines. BI-7273 (10 μM) shows an inhibition below 40% against 31 kinases[1].
细胞实验
Cells are grown in 50 μL medium as specified by the supplier for 7 days starting with 500 and with 1000 cells per well of a 384 well plate in the presence of varying concentrations of compound before measuring viability via cellular ATP levels using the cell titer glow assay.
Cas No.
1883429-21-7
分子式
C20H23N3O3
分子量
353.422
储存和溶解度
Ethanol:65 mg/mL (183.9 mM)
H2O:<1 mgml
DMSO:65 mg/mL (183.9 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
