E-7386 是是一种有口服活性的 CBP/-CATenin 调节剂。

E-7386 is an oral active CBP/ -catenin modulator.

E-7386 is an oral active CBP/ -catenin regulator, which can induce T cells to infiltrate into the tumor in the Wnt1 tumor cogene mouse model and enhance the anti-tumor activity of anti-PD-1 monoclonal antibody.In the Wnt1 model, t-cell infiltration in the vehicle control group was limited, while t-cell infiltration in the E-7386 treatment group was obvious, and E-7386 showed significant anti-tumor activity.

1799824-08-0

C39H48FN9O4

725.85

E7386

DMSO:125 mg/mL (172.21 mM),Need ultrasonic
Methanol:250 mg/mL (344.42 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years