OXFBD04 是 BRD4 (IC50 = 166nM) 的选择性抑制剂，具有抗癌活性。
产品描述
OXFBD04 is a selective inhibitor of BRD4 (IC50 = 166 nM) with anti-cancer activity.
体外活性
OXFBD04 (0.01-100 μM) inhibits the cell growth of cancer cell lines. In MCF7 breast cancer cells, OXFBD04 (10 μM) induces MYC suppression[1].
体内活性
OXFBD04 has optimized physicochemical properties (LE = 0.43; LLE = 5.74; SFI = 5.96), and greater metabolic stability (t1/2 = 388 min, CLint = 3.57 μL/min/mg)[1].
Cas No.
2231747-03-6
分子式
C17H16N2O3
分子量
296.32
储存和溶解度
DMSO:225mg/mL (759.3mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
