Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.

Fidarestat (1 or 4 mg/kg. p.o., daily for 4 weeks) decreases the concentrations of sorbitol and fructose in diabetic rats [2].

136087-85-9

C12H10FN3O4

279.22

SNK 860

DMSO:250 mg/mL (895.35 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years