FT113 是口服具有活力的脂肪酸合酶抑制剂，对全长重组人 FASN 酶的IC50=213 nM。在 BT474 细胞中，它抑制 FASN 的特性，IC50=90 nM。它具有抗增殖作用，在体内和体外实验中，都具有抗癌作用。
产品描述
FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
体内活性
FT113, a compound with potent biochemical and cellular activity, which translated into excellent activity in in vivo models.Caused 32 % and 50% tumor growth inhibition at 25 and 50 mg/kg, respectively in mice.
动物实验
Athymic nude mice bearing MV-411 cells. Dosage:5, 25, or 50 mg/kg, twice daily for 16 days
Cas No.
1630808-89-7
分子式
C22H20FN3O4
分子量
409.417
储存和溶解度
DMSO:62.5 mg/mL (152.66 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
