(±)-Equol 是 equol 的外消旋体。它对 ERα 和 ERβ 的EC50s of 分别为 200 和 74 nM。Equol是大豆异黄酮黄豆苷和大豆黄素的代谢产物。

Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein. (S)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM). (S)-equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.

94105-90-5

C15H14O3

242.3

Equol;(R,S)-Equol;(±)-雌马酚

DMSO:100 mg/mL (412.76 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years