TP-10 是 PDE10A 对其他 PDE 的特异性抑制剂，IC50 为 0.8 nM。
产品描述
TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
体内活性
TP-10 is active in the mouse behavioral model for positive symptoms. TP-10 demonstrates good in vitro and in vivo activity with extremely high intrinsic clearance (CLint) of t>1000 mL/min/kg in mouse liver microsomes (MLM) in assay[1].
Cas No.
898563-00-3
分子式
C26H19F3N4O
分子量
460.45
储存和溶解度
DMSO:95 mg/mL (206.32 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
