ML349 是一种特异性酰基蛋白硫酯酶 2 /溶血磷脂酶 2 抑制剂，其Ki=120 nM。它也是一种 LYPLA2的抑制剂，其IC50=144 nM。
产品描述
ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).
体外活性
ML349 is an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectively. ML349 also is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively. ML348 and ML349 do not reduce cell viability, but they cause a slight activation of AKT in NRAS mutant cells[1][2][3].
Cas No.
890819-86-0
分子式
C23H22N2O4S2
分子量
454.56
储存和溶解度
DMSO:20 mg/mL (44.00 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
