NCT-502 是磷酸甘油酸脱氢酶 (PHGDH) 抑制剂(IC50:3.7 μM)，对 PHGDH 依赖性癌细胞具有细胞毒性，能够减少葡萄糖衍生的丝氨酸的产生，。
产品描述
NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.
体外活性
NCT-502 is cytotoxic to MDA-MB-468 (EC50: 15.2 μM)[1].
Cas No.
1542213-00-2
分子式
C18H20F3N5S
分子量
395.45
别名
N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
储存和溶解度
H2O:< 0.1 mg/mL (insoluble)
DMSO:125 mg/mL (316.10 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
