MG101 是一种有效的半胱氨酸蛋白酶抑制剂，能够抑制钙蛋白酶I (Ki:190 pM)，钙蛋白酶II (Ki:220 pM)，组织蛋白酶B (Ki:150 pM)和组织蛋白酶L (Ki:500 pM)。
产品描述
MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
体外活性
AI-10-49 displays specific growth inhibition of inv(16)-positive cell line ME-1. AI-10-49 selectively binds to CBFβ-SMMHC, disrupts its binding to RUNX1, and restores RUNX1 transcriptional activity. [1]
Cas No.
110044-82-1
分子式
C20H37N3O4
分子量
383.533
别名
Ac-LLnL-CHO;钙蛋白酶抑制剂I;Calpain inhibitor-1;ALLN;Calpain inhibitor I;MG101
储存和溶解度
Ethanol:76 mg/mL (198.15 mM)
DMSO:76 mg/mL (198.15 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
