5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
EPAC 5376753 是 EPAC1 的变构抑制剂，在瑞士 3T3 细胞中的 IC50 为 4 μM。
产品描述
EPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 μM in Swiss 3T3 cells.
体外活性
EPAC 5376753 decreases the conformational changes of EPAC necessary for its activation. EPAC 5376753 inhibits EPAC signaling in cells and EPAC-mediated migration in fibroblasts[1].
Cas No.
302826-61-5
分子式
C15H8Cl2N2O3S
分子量
367.21
别名
5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
