Bufarenogin 是一种从古巴地方性蟾蜍 Peltophryne fustiger 的腮腺分泌物中分离出来的蟾蜍二烯内酯。 Bufarenogin 显示出抗肿瘤活性。

Bufarenogin is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad Peltophryne fustiger. Bufarenogin shows anti-tumor activity.

Bufarenogin caused cell death via apoptosis. Bufarenogin induced B-cell lymphoma 2-associated X protein (Bax)-dependent intrinsic apoptosis, as demonstrated by mitochondrial translocation of Bax and cytoplasm release of HCT116 wild-type cells and cytochrome C. Bufarenogin induced intrinsic apoptosis through the cooperation of Bax and adenine-nucleotide translocator and inhibited the metastasis and growth of orthotopical CRC cells[2].

17008-65-0

C24H32O6

416.51

伪异沙蟾毒精;3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years