NVP 231 是一种强效、特异、可逆的神经酰胺激酶抑制剂，IC50值为12 nM，可竞争性地抑制神经酰胺与 CERK 的结合。它通过增加 DNA 片段和 Caspase-3 和 Caspase-9 的裂解来诱导细胞凋亡。
产品描述
NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.
激酶实验
For deubiquitinase inhibition assays, 19S regulatory particle (5 nM), 26S (5 nM) UCH-L1 (5 nM), UCH-L3 (0.3 nM), USP2CD (5 nM) USP7CD (5 nM) USP8CD (5 nM) or BAP1 (5 nM) is incubated with DMSO or b-AP15 and monitored the cleavage of ubiquitin-AMC (1,000 nM) using a Wallac VICTOR Multilabel counter or a Tecan Infinite M1000 equipped with 380 nm excitation and 460 nm emission filters[1].
Cas No.
362003-83-6
分子式
C25H25N3O2S
分子量
431.55
储存和溶解度
DMSO:41 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
