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Talmapimod
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Talmapimod图片
CAS NO:309913-83-5
包装与价格:
包装价格(元)
1 mg询价
5 mg询价
10 mg询价
25 mg询价
50 mg询价
1 mL*10 mM(in DMSO)询价

他匹莫德
SCIO-469
TalmaPimod 是选择性的,可口服的,ATP 竞争性的p38α抑制剂,IC50值是 9 nM。

产品描述

Talmapimod is a selective, orally active and ATP-competitive inhibitor of p38α(IC50 : 9 nM) .

体外活性

phosphorylation of p38 MAPK inhibited by Talmapimod (100-200 nM; 1 hour) in MM cells[1].In human whole blood, LPS-induced TNF-a production inhibited by Talmapimod [2]. Talmapimod decreases constitutive p38alpha MAPK phosphorylation of both 5T2MM and 5T33MM cells[3].

体内活性

Targeting p38α MAPK with Talmapimod (SCIO-469) decreases myeloma burden,and preventing the development of myeloma bone disease[2]. In 5T2MM and 5T33MM models,Talmapimod inhibits the growth of multiple myeloma and prevents bone diseases[3]. Talmapimod (10-90 mg/kg; p.o.; twice daily orally for 14 days) dose-dependently reduced tumor growth and also dose-dependently reduced weight of the palpable tumors at termination[4].

Cas No.

309913-83-5

分子式

C27H30ClFN4O3

分子量

513

别名

他匹莫德;SCIO-469

储存和溶解度

DMSO:95 mg/mL (185.19 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
 
 
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