SCH-23390 hydrochloride是一种选择性多巴胺D1样受体拮抗剂，对D1和D5受体的Ki分别为 0.2 和 0.3 nM。它还抑制 G 蛋白偶联的内向整流钾通道，IC50为 268 nM。它与5-HT2和5-HT1C受体具有高亲和力，是人5-HT2C受体激动剂，Ki为 9.3 nM。

SCH 23390 hydrochloride is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM).

SCH23390 blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells (IC50=268 nM).SCH 23390 also shows high affinity (Ki=9.3 nM) at h5-HT2C sites.

In the rat, the repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%).

Rats are injected with SCH 23390(0, 1, or 10 μg/kg i.p.).

125941-87-9

C17H19Cl2NO

324.24

R-(+)-SCH23390 hydrochloride

DMSO:32 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years