T-1101 tosylate 是一种具有抗肿瘤活性的Hec1/Nek2抑制剂。
产品描述
T-1101 tosylate is an inhibitor of Hec1/Nek2, with antitumor activity.
体外活性
T-1101 has good oral absorption, along with potent in?vitro antiproliferative activity (IC50: 14.8-21.5?nM).
体内活性
T-1101 tosylate can achieve high concentrations in Huh-7 and MDA-MB-231 tumor tissues, and showed promise in antitumor activity in mice bearing human tumor xenografts of liver cancer (Huh-7).
动物实验
SCID mice bearing human Huh-7, BT-474, MCF-7, and MDA-MB-231 xenografts. Dosage:25 mg/kg, 50 mg/kg. Oral administration; twice per day; 28 days
Cas No.
2250404-95-4
分子式
C31H31N5O6S3
分子量
665.8
别名
TAI-95 tosylate
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
