Parbendazole 是一种有效的microtubule重组抑制剂，能够破坏微管蛋白，EC50值为 530?nM，也是广谱驱虫剂。
产品描述
Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatment of nematode infestations.
体外活性
Parbendazole is a tubulin destabilizer, with an EC50 of 8.79?nM, and can induce DNA damage[1]. Parbendazole (2-10 μM) inhibits the assembly of microtubules dose-dependently, with an IC50 of 3 μM. Parbendazole (2-20 μM)-treated cells show an complete absence of microtubules in Vero cells[2]
Cas No.
14255-87-9
分子式
C13H17N3O2
分子量
247.298
别名
帕苯咪唑;SKF 29044
储存和溶解度
DMSO:4 mg/mL (16.18 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
