产品描述
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1).
体外活性
AZ82 specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome numbers, such as HeLa [1]. AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes for mant-ATP binding/releasing (IC50: 0.90 μM/1.26 μM) [2].
Cas No.
1449578-65-7
分子式
C28H31F3N4O3S
分子量
560.63
储存和溶解度
DMSO:125 mg/mL (222.96 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
