Darunavir Ethanolate 是一种HIV蛋白酶抑制剂，可以用于 HIV/AIDS 的相关研究。对野生型 HIV-1 蛋白酶的Ki值为1 nM。
产品描述
Darunavir ethanolate is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.
体内活性
Darunavir is effective against wild-type and PI-resistant HIV, and has an oral bioavailability of 37%. It needs to be used in combination with ritonavir, which increases the bioavailability to 82%[3].
Cas No.
635728-49-3
分子式
C29H43N3O8S
分子量
593.74
别名
地瑞那韦乙醇盐;达芦那韦乙醇;UIC 94017;Darunavir Ethanolate;TMC114
储存和溶解度
DMSO:93 mg/mL (156.6 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
