Besifovir 是由 LB80380 转化而来的一种 LB80380 母体药物，进一步代谢为其活性形式 LB80317。LB80380 是抗乙型肝炎病毒的抗病毒药物。
产品描述
Besifovir, a parent drug converted by LB80380, further metabolizes to its active form, LB80317. LB80380 is potent antiviral agent against hepatitis B virus (HBV).
体内活性
Besifovir (LB80380) is a relatively new oral acyclic nucleotide phosphonate. Areas covered: LB80380 is a prodrug of LB80331 and LB80317. It is rapidly absorbed when taken orally. Escalating doses of besifovir produce linear increase of the plasma concentration. Doses above 60mg are effective for inhibiting HBV in human. Using 60mg as an example, the maximal concentration of LB80331 in plasma is 397 ng/mL.
Cas No.
441785-25-7
分子式
C10H14N5O4P
分子量
299.227
储存和溶解度
DMSO:250 mg/mL (835.51 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
