GLP-26 是一种HBV衣壳组装调节剂，抑制 Hep AD38 系统中的 HBV DNA 复制，IC50值为3 nM。 在 1 μM 时，使 cccDNA 降低>90％。它破坏前基因组 RNA 的衣壳化，导致核衣壳解体，并减少 cccDNA 库。
产品描述
GLP-26, an HBV capsid assembly regulator (CAM), inhibits HBV DNA replication (IC50=3 nM) in the Hep AD38 system and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pregenomic RNA, leading to nucleocapsid disassembly and reducing the cccDNA library.
体外活性
Administration of 0.7-1.7 μM GLP-26 for 3 days reduces secreted HBeAg in HepNTCP-DL cells transfected with HBV wild type with EC50 values of 0.7 μM[1].
Cas No.
2133017-36-2
分子式
C19H17F2N3O3
分子量
373.35
储存和溶解度
DMSO:100 mg/mL (267.85 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
