Clobetasol propionate 是CYP3A5的选择性抑制剂(IC50:0.206 μM)，而对 CYP3A4 或其他主要 CYP无抑制作用。它是皮质类固醇，对于牛皮癣和其他皮肤病具有潜在的研究价值。

Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.

25122-46-7

C25H32ClFO5

466.97

Clobetasol 17-propionate;Temovate;Dermovate;CCl 4725;CGP9555;丙酸氯倍他索

H2O:<1 mgml
DMSO:86 mg/mL (184.2 mM)
Ethanol:16 mg/mL (34.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years