Terevalefim 是干细胞生长因子的一种类似物，对c-Met受体有选择性激活作用。
产品描述
Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.
体外活性
Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs[2].
体内活性
Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models[1].Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats[2].
Cas No.
1070881-42-3
分子式
C9H8N2S
分子量
176.24
储存和溶解度
DMSO:100 mg/mL (567.41 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
