PF-04979064 是一种选择性PI3K/mTOR双重激酶抑制剂，能够抑制 PI3Kα (Ki=0.13 nM) 和 mTOR (Ki=1.42 nM)。
产品描述
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
体内活性
PF-04979064 was tested against human class I PI3K isoforms α, γ, and δ, with PI3Kα Ki of 0.130 nM, PI3Kγ Ki of 0.111 nM, and PI3Kδ Ki of 0.122 nM.PF-04979064 was progressed to rat in vivo PK studies and exhibited robust PK profile: Vdss = 5.23 L/kg, Cl = 19.3 mL/min/kg, T1/2 = 1.85 h, and F % = 61%.
Cas No.
1220699-06-8
分子式
C24H26N6O3
分子量
446.5
储存和溶解度
DMSO:11 mg/mL (24.64 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
