L-368,899 hydrochloride, used as a tocolytic agent, is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively.

L-368,899 is less active on VP receptor in human liver and kidney, rat liver and kidney (IC50, 510 nM, 960 nM, 890 nM, 2400 nM, respectively).L-368,899 hydrochloride is a potent, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively.

160312-62-9

C26H43ClN4O5S2

591.23

DMSO:130 mg/mL (219.88 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years