GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insulin sensitivity, and glucose response to feeding in ob/ob mice.

TP2020

C225H342N62O64S

4971.62

H2O:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years